A gap-filling, regenerative implant for open-wedge osteotomy
نویسندگان
چکیده
IntroductionIn patients suffering from unilateral osteoarthritis in the knee, an osteotomy can provide symptomatic relief and postpone need for replacement of joint. Nevertheless, open-wedge osteotomies (OWOs) around knee joint face several challenges like postoperative pain bone nonunion.ObjectivesIn this study, aim was to design, fabricate, evaluate a gap-filling implant OWO using osteoinductive degradable biomaterial.MethodsDesign porous wedge-shaped implants based on computed tomography scans cadaveric legs. Implants were 3-dimensionally printed magnesium strontium phosphate-polycaprolactone (MgPSr-PCL) biomaterial ink. Standardized scaffolds with different inter-fiber spacing (IFS) mechanically characterized properties assessed vitro. Finally, human-sized heights (5 mm, 10 15 mm) designed fabricated ex vivo implantation during 3 procedures human legs.ResultsImplants interior IFS-1.0 resulted that maintained top bottom porosity, while exhibited significant mechanical stability. Bone marrow concentrate culture expanded mesenchymal stromal cells attached MgPSr-PCL material proliferated over 21 days culture. The production osteogenic markers alkaline phosphatase activity, calcium, osteocalcin promoted all conditions, independent induction medium. planned wedges implanted procedures. A small fraction one side resected assure fit into proximal biplanar gap. Preplanned wedge after as measured by micro-computed tomography.ConclusionTo conclude, personalized OWOs successfully manufactured. supported osteogenesis vitro full-size implemented surgical procedure without compromising preplanned height.
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ژورنال
عنوان ژورنال: Journal of cartilage & joint preservation
سال: 2023
ISSN: ['2667-2545']
DOI: https://doi.org/10.1016/j.jcjp.2023.100117